There is one Premiership fixture scheduled for Friday evening with high-riding Gloucester hosting eighth-placed Exeter Chiefs at Kingsholm.
Gloucester head coach George Skivington has made four changes to his starting XV from their win over London Irish for the match against the dangerous Chiefs.
Harry Elrington replaces last week’s Player of the Match, Val Rapava-Ruskin, at loosehead prop, who is away on England duty along with hooker Jack Singleton.
Santiago Socino, who scored two tries against Irish, and Fraser Balmain complete the front-row.
Freddie Clarke remains in the second-row for the Cherry and Whites. Alongside Clarke, academy graduate Cam Jordan comes in for Matias Alemanno at lock.
In the back-row, club captain Lewis Ludlow starts at openside, with Ruan Ackermann moving from number eight to blindside and Ben Morgan replacing Jordy Reid.
Charlie Chapman and last Friday’s match winner Adam Hastings start as half-backs with Giorgi Kveseladze and Chris Harris in the centre.
With Jonny May out injured, Santiago Carreras moves out to the wing and Lloyd Evans comes in at full-back. Louis Rees-Zammit starts on the right wing.
On the bench, Henry Walker, Kirill Gotovtsev and Tom Seabrook are in line for their first Premiership minutes of the season.
Ciaran Knight, Matias Alemanno, Albert Tuisue, Ben Meehan and Jack Reeves complete the replacements.
Exeter missing four England call-ups
Meanwhile, Exeter are without four players due to England call-ups as Luke Cowan-Dickie, Jack Nowell, Sam Simmonds and Henry Slade miss out this week.
Slade was called in on Monday having initially missed out on Eddie Jones’ selection plans, which means a handful of changes are needed from the Saracens loss.
However, fellow internationals Christ Tshiunza (Wales) and Stuart Hogg and Jonny Gray (both Scotland) are available and will take their place in the matchday squad, which includes a starting debut for Australian international loosehead prop Scott Sio.
He is one of three changes to the Chiefs pack, joining skipper Jack Yeandle in the front-row and Lewis Pearson, who is added to the back-row in place of Tshiunza, who is named on the bench.
Behind the scrum, Rory O’Loughlin comes into centre in place of Slade, whilst the absence of Nowell is countered with the return to fitness of Josh Hodge, who has happy memories of scoring at Kingsholm back in March 2021.
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On the bench, Dan John is also included for the first time in a Premiership squad this season.
Form: Gloucester Rugby’s only defeat in Premiership Rugby this campaign was 39-41 away at Saracens in Round Three. Gloucester have lost only once at Kingsholm in Premiership Rugby since January: 21-27 to Wasps on 2 April. Exeter Chiefs have lost two of their last three fixtures in Premiership Rugby but have won two of their last three away from home in the competition. The Chiefs have lost only one of their last six encounters with Gloucester in Premiership Rugby: 18-34 at Kingsholm in March 2021. The Chiefs have won on two of their last three visits to Kingsholm.
The teams:
Gloucester: 15 Lloyd Evans, 14 Louis Rees-Zammit, 13 Chris Harris, 12 Giorgi Kveseladze, 11 Santi Carreras, 10 Adam Hastings, 9 Charlie Chapman, 8 Ben Morgan, 7 Lewis Ludlow (c), 6 Ruan Ackermann, 5 Cam Jordan, 4 Freddie Clarke, 3 Fraser Balmain, 2 Santiago Socino, 1 Harry Elrington
Replacements: 16 Henry Walker, 17 Ciaran Knight, 18 Kirill Gotovtsev, 19 Matias Alemanno, 20 Albert Tuisue, 21 Ben Meehan, 22 Jack Reeves, 23 Tom Seabrook
Exeter Chiefs: 15 Stuart Hogg, 14 Josh Hodge, 13 Rory O’Loughlin, 12 Ian Whitten, 11 Olly Woodburn, 10 Harvey Skinner, 9 Jack Maunder, 8 Jacques Vermeulen, 7 Lewis Pearson, 6 Dave Ewers, 5 Jonny Gray, 4 Ruben Van Heerden, 3 Harry Williams, 2 Jack Yeandle (c), 1 Scott Sio
Replacements: 16 Jack Innard, 17 Alec Hepburn, 18 Josh Iosefa-Scott, 19 Jack Dunne, 20 Christ Tshiunza, 21 Sam Maunder, 22 Joe Simmonds, 23 Dan John
Venue: Kingsholm
Kick-off: 19:45 BST (18:45 GMT)
Referee: Adam Leal
Assistant referees: Dan Jones, John Meredith
TMO: Dean Richards